Primo's Pharmaceutical Technology

Primo specializes in the development, manufacturing, and commercialization of Radiopharmaceutical Drug Conjugates (RDC), driving continuous innovation in the field of cancer precision medicine. Leveraging our international-standard facilities and cutting-edge expertise, we are dedicated to advancing molecular imaging and targeted therapy—bringing new hope and superior treatment outcomes to cancer patients worldwide.

RDC Synergizes Targeting, Diagnostics, and Therapeutics

Integrating targeting, diagnostics, and therapeutics, RDC technology represents a next-generation paradigm in targeted cancer therapy. By leveraging targeting molecules such as antibodies or peptides, RDCs deliver radioisotopes precisely to cancer cells. This enables localized radiotherapy that maximizes tumor destruction while significantly minimizing damage to healthy cells.

RDC Structure

The RDC structure is composed of four critical elements: Target Ligand, Linker, Chelator, and Radionuclide.

Linker

Acting as the essential bridge between the targeting ligand and the radionuclide, the Linker regulates the drug’s metabolism and distribution. Its architecture and design are paramount to the successful development of RDCs. At Primo, we prioritize Linker innovation and quality to ensure superior stability in absorption and metabolic performance in vivo.

Target Ligand

Targeting ligands—which can be antibodies, small molecules, or peptides—bind specifically to receptors, enzymes, or proteins associated with particular tumors or cells within the tumor microenvironment. This specificity provides the drug with exceptional selectivity and precision-targeting capabilities directed at cancer cells.

Chelator

Chelation is a bonding process between a metal ion and other molecules, forming multiple bonds between the ligand and a central metal atom. Chelators are widely utilized in novel conjugate drugs and are especially critical for RDCs, as they securely bridge the radionuclide to the targeting moiety, ensuring complex stability.

Radionuclide

RDC therapy works by leveraging ionizing radiation released from radionuclides to destroy tumor cells.

Mechanism of Action

While conventional External Beam Radiation Therapy (EBRT) is an established and effective cancer treatment, it requires high-energy beams to pass through skin and healthy tissue from outside the body.

In contrast, Radionuclide Drug Conjugates (RDC) utilize an endogenous approach. Administered via intravenous injection, the drug targets tumor lesions directly from within, significantly minimizing collateral damage to surrounding healthy organs.

The drug delivery mechanism of RDC mirrors that of Antibody-Drug Conjugates (ADC).

RDC Advantages

✓ Precision Tumor Targeting with Minimal Side Effects

✓ Controllable Efficacy and Optimized Toxicity Profile

✓ High Potential for Metastatic and Refractory Cancers

 

Key Types of Radiation Emissions

Radioligand Theranostics

Examples include Actinium-225, Radium-223

Characteristics of Alpha Particles:
High Linear Energy Transfer(High LET)
Ultra-short Range(50–100 μm)
Potent Cytotoxicity: Direct DNA Double-Strand Breaks
Ideal for Localized Treatment and Micro-metastases
Penetration in Bulky Tumors:If targeting molecules cannot penetrate deep into the tumor core, the limited range may not fully eradicate large, solid tumor masses.
Radioligand Theranostics

Examples include Lutetium-177, Yttrium-90, Strontium-89

Characteristics of Beta Particles:
Moderate Linear Energy Transfer (Moderate LET)
Extended Range and the "Crossfire Effect"
Indirect DNA Damage via Free Radicals
Ideal for Tumors of Bulky or Metabolic Heterogeneity
Radioligand Theranostics

Examples include Indium-111, Iodine-125, Gallium-67

Characteristics of Auger Electrons:
Ultra-low Energy and Nanometric Range(less than 1 μm, often at the sub-nanometer scale)
Biological effectiveness is highly distance-dependent, relying on the proximity to the cell's DNA.
With nearly zero impact on normal tissues, Auger emitters are particularly effective for high water-content tumors

Technical and Advantages of RLT

As an extension of RDC technology, Radioligand Theranostics (RLT) possesses a unique dual-functionality: by simply swapping the radionuclide, the same molecular conjugate can transition from high-resolution diagnostic imaging to potent targeted therapy.

Diagnostic Precision

  • Common Isotopes: 18F, 68Ga
  • Mechanism: Typically utilized in Positron Emission Tomography (PET) scans.
  • Clinical Value: Offers exceptional image resolution to precisely localize lesions. This allows physicians to confirm the presence and extent of the disease, providing accurate visual data for clinical decision-making.

Therapeutic Potency

  • Common Isotopes: 225Ac, 177Lu
  • Mechanism: Emits Alpha (α)or Beta (β) particles specifically to destroy cancer cells or diseased tissue.
  • Clinical Value: These radionuclides are engineered to focus energy directly at the cancer site, delivering a lethal dose to the tumor while preserving surrounding healthy tissue.

Our Mission

Primo is dedicated to advancing cancer care through the innovation of Radioligand Therapy (RLT). We believe that RLT technology can unlock a broader therapeutic window, providing safer and more effective treatment options compared to existing standards of care.

Technical Advantages of Primo

Primo’s proprietary Radioligand Therapy (RLT) technology facilitates the rapid clearance of radionuclides that do not bind specifically to cancer cells.

Engineered for precision, this technology clears unbound radionuclides significantly faster than existing commercial platforms, effectively expanding the therapeutic window.

We maintain an extensive library of proprietary linker molecules, allowing us to optimize clearance pathways and kinetics tailored to various targeting moieties.

Primo applies this technology across a wide array of molecules and categories—including antibodies and small molecules—continuously innovating to address diverse cancer types and complex clinical challenges.

 

1/

Enhanced Tumor Killing Efficacy

Leveraging α-particle radiation to deliver high-potency destruction of tumor cells.
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Versatile Target Adaptability

Compatible with diverse targeting moieties, including antibodies and small molecules.
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Broad Tumor Applications

Applicable across multiple tumor types, expanding clinical treatment options.
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Comprehensive Supply Chain

Established stable manufacturing processes and a secure radionuclide supply chain.
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Precision Diagnostic Screening

Integrating advanced imaging technologies to effectively identify and target the optimal patient population.